In Vivo Histopathological Wound Healing in Mice (Mus Musculus) of Suruhan Extract (Peperomia Pellucida L. Kunth)

DOI

10.2991/ahsr.k.220303.009How to use a DOI?

Keywords

Wound Healing; Wound; Histopathology Scoring; Suruhan (Peperomia Pellucida)

Abstract

A wound is a condition where the continuity of tissue is broken, which disrupts the function and anatomical structure of the body from the outermost surface to the deepest layer. When an injury occurs, the body will carry out a healing process consisting of four stages: haemostasis, inflammation, proliferation, and maturation. The wound healing process can be accelerated, one of which is using a messenger plant (Peperomia pellucida) which has a pharmacological function. The purpose of the study was to prove the difference between the administration of extracts and 10% povidone-iodine on the histopathological score of wound healing in mice (Mus musculus) 3,5,7 and 14 days. The type of research was true experimental with a post-test control group design. The sampling technique used is simple random sampling. The research sample was 32 mice (Mus musculus) male sex, healthy, 2-3 months old with a bodyweight of 20-40 g, divided into two groups, namely the treatment group and the control group where each group consisted of 4 subgroups. The treatment group was the group that was given 10% messenger extract topically once a day for 14 days. The control group was the group that was given 10% povidone-iodine once a day for 14 days. Skin tissue was taken and prepared with hematoxylin-eosin staining for histopathological examination, including epithelialization, granulation, inflammatory cells, and angiogenesis. The results of the study were analyzed by using the Mann-Whitney test. The results of the Mann-Whitney test showed p values on day 3 (p=0,200), day 5 (p=0,057), day 7 (p=0,029) and day 14 (p=0,343). In general, there is no significant difference in histopathological scores between the control group and the treatment group.

Copyright

© 2022 The Authors. Published by Atlantis Press International B.V.

Open Access

This is an open access article under the CC BY-NC license.

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TY  - CONF
AU  - Dessy Abdullah
AU  - Nadia Purnama Dewi
AU  - Ade Teti Vani
AU  - Helvina Amalia
PY  - 2022
DA  - 2022/03/08
TI  - In Vivo Histopathological Wound Healing in Mice (Mus Musculus) of Suruhan Extract (Peperomia Pellucida L. Kunth)
BT  - Proceedings of 1st International Conference on Health Sciences and Biotechnology (ICHB 2021)
PB  - Atlantis Press
SP  - 46
EP  - 51
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.220303.009
DO  - 10.2991/ahsr.k.220303.009
ID  - Abdullah2022
ER  -