Optimization of Centella asiatica (L.) Urban Dosage in Improving Memory of Mice with Brain Necrosis Model
- DOI
- 10.2991/978-94-6463-148-7_44How to use a DOI?
- Keywords
- Brain necrosis; Centella asiatica (L.) Urban extract (EkCa); Memory; Streptozotocin
- Abstract
Brain necrosis in mice can be triggered by injection of streptozotocin (STZ), causing nerve cell injury that can trigger neurodegenerative diseases. Centella asiatica (L.) Urban is one of the herbs whose triterpenoid compounds have neuroregenerative activity, so it is widely used as Centella asiatica (L.) Urban extract (EkCa). The aim of this study was to determine the optimization of EkCa dose in improving memory of mice in brain necrosis model. The design of this study was completely randomized design with 36 male Balb/C strain mice weighing 25–30 g with 6 treatments (control, EkCa 20, 30, 40 mg/kgBW, and metformin 25 mg) with each treatment repeated 6 times. Brain necrosis mice were made by injecting multiple doses of STZ intraperitoneally at a dose of 40 mg/kgBW for 3 days and 60 mg/kgBW for 2 consecutive days. Memory was obtained from the calculation of retention time (RT-LT > 0). Data analysis used One Way Anova test followed with Duncan test. The results showed that the optimum dose was 30 mg/kgBW (P < 0.05). From the results of the study, it can be concluded that EkCa has neuroregenerative activity so that it can improve the memory of mice with brain necrosis model.
- Copyright
- © 2023 The Author(s)
- Open Access
- Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.
Cite this article
TY - CONF AU - Bayyinatul Muchtaromah AU - Ely Nuril Fajriyah AU - Wahyuni Risalatul Azmah AU - Maharani Retna Duhita AU - Arif Nur Muhammad Ansori AU - Tanjina Sharmin PY - 2023 DA - 2023/05/29 TI - Optimization of Centella asiatica (L.) Urban Dosage in Improving Memory of Mice with Brain Necrosis Model BT - Proceedings of the 12th International Conference on Green Technology (ICGT 2022) PB - Atlantis Press SP - 443 EP - 451 SN - 2352-5401 UR - https://doi.org/10.2991/978-94-6463-148-7_44 DO - 10.2991/978-94-6463-148-7_44 ID - Muchtaromah2023 ER -