Expression and Clinical Significance of KISS-1 and TIMP-1 in Colon Carcinoma

DOI

10.2991/icessms-16.2017.34How to use a DOI?

Keywords

Colon Carcinoma, KISS-1, TIMP-1, Occurrence, Development, Invasion, Metastasis

Abstract

Objective: To detect the expression of KISS-1 and mRNA TIMP-1 and protein in colon carcinoma, and to explore its clinical significance. Methods: The application of Realtime PCR was detected in 45 cases of colon carcinoma, adjacent atypical hyperplasia and normal colonic mucosa in KISS-1 and the expression of TIMP-1mRNA, SP method was used to detect KISS-1 and TIMP-1 protein expression, correlation analysis, and its occurrence and development of colon cancer invasion and metastasis and the relationship between the two. Results: The KISS-1mRNA and protein expression in normal colon mucosa, atypical hyperplasia and carcinoma were gradually decreased, there were significant differences between the groups (P < 0.05); the expression of KISS-1mRNA and protein and colon cancer invasion and lymph node metastasis (P < 0.05). The TIMP-1mRNA and protein expression in normal colon mucosa, atypical hyperplasia and carcinoma was also decreased, the difference between groups was statistically significant (P < 0.05); the expression of TIMP-1mRNA protein in colon carcinoma and invasive depth and lymph node metastasis (P < 0.05). The protein expression was positively correlated. Conclusion: The expression of KISS-1, TIMP-1mRNA and protein is closely related to the occurrence, development, invasion and metastasis of colon cancer.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Yanxin Zhang
AU  - Yan Zhao
PY  - 2017/02
DA  - 2017/02
TI  - Expression and Clinical Significance of KISS-1 and TIMP-1 in Colon Carcinoma
BT  - Proceedings of the 2016 2nd International Conference on Education, Social Science, Management and Sports (ICESSMS 2016)
PB  - Atlantis Press
SP  - 162
EP  - 165
SN  - 2352-5398
UR  - https://doi.org/10.2991/icessms-16.2017.34
DO  - 10.2991/icessms-16.2017.34
ID  - Zhang2017/02
ER  -