Analysis of the Clinical Effect of Bad Cold Resistance Mixture on Exogenous High Fever Animal Model
- DOI
- 10.2991/icemct-17.2017.136How to use a DOI?
- Keywords
- exogenous high fever, bad cold resistance mixture, animal model, febrile medium
- Abstract
Objective: Analyzing the function of bad cold resistance mixture on exogenous high fever of young mice febrile medium and discussing the characteristics and security of bad cold resistance mixture abatement of fever to provide clinical basis for comprehensive exploitation and utilization of bad cold resistance mixture capsule. Methods: Through the lipopolysaccharide (LPS) intraperitoneal injection to build exogenous high fever animal model and measure the temperature changes in different time points of animal model, besides, measure the interleukin 1 IL-1 , total white blood cell number in peripheral serum to learn the antifebrile effect of bad cold resistance mixture. Result: For bad cold resistance mixture of 10 ml/kg and 14 ml/kg group of big mice, after taking medicine, the body temperature are all lower than that of control group (P < 0.05) in the same time points; For the big mice in Aspirin group and bad cold resistance mixture in four time points of 0.5 h, 1 h, 2 h, 3 h, the change situation of big mice temperature is lower than that of control group (P < 0.05). For different medicated groups, after 3 hours' medicine taking for the animal models, the content of IL-1 and total white cell number in the peripheral blood has different degree of decrease to some extent by comparing with that of control group, among which, the influence of bad cold resistance mixture 14 ml/kg group on the white cell content in peripheral blood is more obvious (P < 0.05). Bad cold resistance mixture 6 ml/kg, 10 ml/kg and 14 ml/kg groups can significantly reduce the content(P > 0.05) of IL-1 in the peripheral blood of big mice, which has no significant difference (P > 0.05) compared with the aspirin and ShuangHuangLian groups. Conclusion: The function of bad cold resistance mixture on the exogenous high fever of animal model can significantly inhibit the increase of body temperature and achieve the goal of antiphlogosis and abatement of fever.
- Copyright
- © 2017, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Hua-ming Xu AU - Jun-ying Song AU - Lin Li AU - Han-wei Li PY - 2017/05 DA - 2017/05 TI - Analysis of the Clinical Effect of Bad Cold Resistance Mixture on Exogenous High Fever Animal Model BT - Proceedings of the 2017 4th International Conference on Education, Management and Computing Technology (ICEMCT 2017) PB - Atlantis Press SP - 626 EP - 631 SN - 2352-5398 UR - https://doi.org/10.2991/icemct-17.2017.136 DO - 10.2991/icemct-17.2017.136 ID - Xu2017/05 ER -