Proceedings of the 3rd International Conference on Cardiovascular Diseases (ICCvD 2021)

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Increased D-Dimer in Covid-19 Patients: Article Review

Authors
Farida Juliantina Rachmawaty1, *, Reza Ishak Estiko2, Rana Aulia Farah Kamila2
1Department of Microbiology, Faculty of Medicine, Universitas Islam Indonesia, Yogyakarta, Indonesia
2Faculty of Medicine, Universitas Islam Indonesia, Yogyakarta, Indonesia
*Corresponding author. Email: farida.juliantina@uii.ac.id
Corresponding Author
Farida Juliantina Rachmawaty
Available Online 19 December 2022.
DOI
10.2991/978-94-6463-048-0_31How to use a DOI?
Keywords
COVID-19; D-Dimer; Hypercoagulability
Abstract

COVID-19, which was first discovered in Wuhan, China in December 2019, has infected more than 200 countries. The virus that causes it is the Severe Acute Respiratory Syndrome Corona Virus 2 or better known as SARS-CoV-2. Symptoms in infected individuals vary widely from asymptomatic to severe ones. Individuals infected with COVID-19 may develop hypercoagulability and thrombosis. D-dimer is a degradation product of fibrin which indicates the formation of thrombin and dilution of fibrin by plasmin. Literature search was done in PubMed and Google Scholar from January 2020 to October 2021. The search method used the Boolean operators to link titles and abstracts with the keywords “D-Dimer” AND “COVID-19”. The year of publication was all after 2019. The types of research were not limited, so all sources, meta-analyses, reviews, original articles, and reports, were collected.In COVID-19 patients, D-dimer can be an early marker to improve the management of COVID-19 patients. D-dimer can serve as a marker to determine the severity of lung damage. An increase in D-dimer indicates a degradation of accumulated fibrin in the alveoli and lung parenchyma as a result of lung trauma due to the reaction between the immune system and SARS-Cov-2 in the alveoli or lung parenchyma. The results showed that elevated plasma D-dimer levels were more common in patients with severe COVID-19 cases. The D-dimer is positively correlated with the prognosis of COVID-19. A fourfold increase in D-dimer or greater predicts in-hospital mortality.

Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 3rd International Conference on Cardiovascular Diseases (ICCvD 2021)
Series
Advances in Health Sciences Research
Publication Date
19 December 2022
ISBN
978-94-6463-048-0
ISSN
2468-5739
DOI
10.2991/978-94-6463-048-0_31How to use a DOI?
Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Farida Juliantina Rachmawaty
AU  - Reza Ishak Estiko
AU  - Rana Aulia Farah Kamila
PY  - 2022
DA  - 2022/12/19
TI  - Increased D-Dimer in Covid-19 Patients: Article Review
BT  - Proceedings of the 3rd International Conference on Cardiovascular Diseases (ICCvD 2021)
PB  - Atlantis Press
SP  - 263
EP  - 268
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-048-0_31
DO  - 10.2991/978-94-6463-048-0_31
ID  - Rachmawaty2022
ER  -