Acetylation of Asiatic Acid and Its Hepatotoxicity Prediction

DOI

10.2991/iccst-15.2015.10How to use a DOI?

Keywords

Acetylation, ADMET prediction, Asiatic acid

Abstract

Asiatic acid (AA) is one of the triterpenoids isolated from pegagan (Centella asiatica (L.) Urb.), which has the antiinflammatory activity. The present studies were aimed to synthesize triacetyl asiatic acid (2,3,23-triacetooxy-12-ene asiatic acid) and to predict its hepatotoxicity properties. Acetylation was carried out using acetic acid anhydride and ZnCl2 as a catalyst, while the hepatotoxicity properties were studied using Accelrys Discovery Studio 2.5 software. The structure was elucidated with IR, Mass and NMR spectroscopic methods. The results showed that the product of synthesis was confirmed as triacetyl asiatic acid, and the yield was 31.79%. The prediction of its hepatotoxicity revealed that triacetyl asiatic acid is less hepatotoxic than AA.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Ida Musfiroh
AU  - Ita Puspitasari
AU  - Ahmad Muhtadi
AU  - Rahmana E. Kartasasmita
AU  - Slamet I. Surantaatmadja
PY  - 2015/01
DA  - 2015/01
TI  - Acetylation of Asiatic Acid and Its Hepatotoxicity Prediction
BT  - Proceedings of the 3rd International Conference on Computation for Science and Technology
PB  - Atlantis Press
SP  - 45
EP  - 48
SN  - 2352-538X
UR  - https://doi.org/10.2991/iccst-15.2015.10
DO  - 10.2991/iccst-15.2015.10
ID  - Musfiroh2015/01
ER  -