The Comparison Between Anti-Inflammatory Effects of Ethanol Extract from Kaempferia galanga L. and Diclofenac Sodium Induced by Carrageenan

DOI

10.2991/ahsr.k.200204.005How to use a DOI?

Keywords

Kaempferia galanga L, plethysmometer, diclofenac sodium

Abstract

Steroid and non-steroid anti-inflammatory drugs have many side effects so that many anti-inflammatory developments are made from natural ingredients, especially in plants. Plants that are scientifically proven to have antiinflammatory characteristic, one of which is from Zingiberaceae family. Kencur (Kaempferiae galangal L.) is a type of herb and medicinal plant that has been widely recognized by Indonesian people. Further research needs to be conducted to determine the comparison of the effectiveness of kencur extract with sodium diclofenac as an anti-inflammation. The parameter observed in this study was inhibition of edema on the rat’s foot after induced by 0.1 mL of 1% carrageenan for 390 minutes. Edema volume was measured by using a plethysmometer. A total of 15 male rats weighing 200–250 gr were divided into 5 groups, namely the negative control group who were only given a PGA of 2%, the positive control which given sodium diclofenac 20mg / Kg of weight, and the extract group dose of kencur rhizomes respectively 45, 90 and 180 mg / kg. Edema volume measurement was performed every 30 minutes to 390 minutes. Edema volume data was used to calculate the percentage of edema inhibition, then the data were analyzed using one-way ANOVA and followed by LSD test to see the differences between groups. Ethanol extract of kencur with doses of 45 and 90 mg / Kg of weight at the 5th and 6th hours showed significantly different anti-inflammatory activity compared to the positive controls where the p value <0.005. This result shows that the ethanol extract of kencur can be used as an anti-inflammatory agent in male rats.

Copyright

© 2020, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Galih Samodra
AU  - Dina Febrina
PY  - 2020
DA  - 2020/02/10
TI  - The Comparison Between Anti-Inflammatory Effects of Ethanol Extract from Kaempferia galanga L. and Diclofenac Sodium Induced by Carrageenan
BT  - Proceedings of the 1st International Conference on Community Health (ICCH 2019)
PB  - Atlantis Press
SP  - 18
EP  - 22
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.200204.005
DO  - 10.2991/ahsr.k.200204.005
ID  - Samodra2020
ER  -