Pharmacokinetic Drugs Interaction and Management in Margono Soekarjo Hospital in Stroke Patients

DOI

10.2991/ahsr.k.200204.002How to use a DOI?

Keywords

drug interaction, hospital, pharmacokinetic, stroke

Abstract

Stroke is a functional brain disorder in the form of nerve paralysis (neurologic deficit) due to blocked blood flow to the brain. Therapy in stroke patients usually gets more than two kinds of drugs so that drug interactions often occur. One mechanism of drug interaction is pharmacokinetics. Pharmacokinetic interactions occur when a drug affects the absorption, distribution, metabolism and excretion of other drugs thereby increasing or decreasing the amount of drug available to produce its pharmacological effects. This study aims to determine the potential pharmacokinetic drug interaction and management in stroke patients in Margono Soekarjo Hospital. The method of this study was descriptive study with cross sectional approach (1–30 June 2019). Data were analyzed descriptively using Stockley’s Drug Interaction, Drug Interaction Facts and www.drugs.com database. Medscape Drug Interactions Checker. The results showed that from 27 stroke patients there were 38.60% pharmacokinetic interaction events. The most common pharmacokinetic interaction was interaction between mecobalamin and ranitidine.

Copyright

© 2020, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Desy Nawangsari
AU  - Ikhwan Yuda Kusuma
PY  - 2020
DA  - 2020/02/10
TI  - Pharmacokinetic Drugs Interaction and Management in Margono Soekarjo Hospital in Stroke Patients
BT  - Proceedings of the 1st International Conference on Community Health (ICCH 2019)
PB  - Atlantis Press
SP  - 5
EP  - 8
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.200204.002
DO  - 10.2991/ahsr.k.200204.002
ID  - Nawangsari2020
ER  -