Effect of pH Value and Doxorubicin/Hydroxyapatite Ratio on the Release of Doxorubicin from Hydroxyapatite Surface in Phosphate Buffered Saline (PBS)

DOI

10.2991/iccelst-st-19.2019.7How to use a DOI?

Keywords

hydroxyapatite, mass transport, doxorubicin, release, drug delivery

Abstract

Hydroxyapatite (HA) can be used as drug delivery material in cancer treatment by adsorption of cancer drugs such as doxorubicin (DOX) to hydroxyapatite surface. This experiment studied the effect of pH value and DOX/HA ratio on the release rate of doxorubicin from hydroxyapatite in phosphate buffered saline (PBS). The release of doxorubicin from hydroxyapatite surface was done by soaking DOX-HA powder into 350 mL of PBS solution at pH 5.6 and 7.4 in a beaker glass. The sample was taken from the suspension every two hours for 120 hours. The samples were analyzed using UV-Vis spectrophotometer to determine the DOX concentration released. The DOX-HA powder was characterized using SEM-EDX. At lower the pH value the higher DOX concentration released. DOX concentration released in the first 40 hours were maintained at 1.25 and 6.92 ppm for pH value 7.4 and 5.6 respectively. Beside that, the more hydroxyapatite used the higher DOX concentration released. The DOX concentration released in the first 40 hours at pH value 7.4 was maintained at 0.625, 3.541, 4.508 and 4.958 ppm when using 0.2, 0.3, 0.4 and 0.5 gram of hydroxyapatite respectively.

Copyright

© 2019, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Ahmad Fadli
AU  - Silvia Reni Yenti
AU  - Rozanna Sri Irianty
AU  - Nursyaniati
AU  - Ulfah Naida Marbun
PY  - 2019/12
DA  - 2019/12
TI  - Effect of pH Value and Doxorubicin/Hydroxyapatite Ratio on the Release of Doxorubicin from Hydroxyapatite Surface in Phosphate Buffered Saline (PBS)
BT  - Proceedings of the International Conference of CELSciTech 2019 - Science and Technology track (ICCELST-ST 2019)
PB  - Atlantis Press
SP  - 34
EP  - 37
SN  - 2352-5401
UR  - https://doi.org/10.2991/iccelst-st-19.2019.7
DO  - 10.2991/iccelst-st-19.2019.7
ID  - Fadli2019/12
ER  -