Interaction on biomarkers in goldfish after co-exposure to 17β-estradiol and benzo(a)pyrene
- DOI
- 10.2991/iccahe-16.2016.49How to use a DOI?
- Keywords
- 17β-estradiol; ethoxyresorufin-O-deethylase; benzo(a)pyrene; vitellogenin
- Abstract
The aquatic environment is challenged with complex mixtures of pollutants, which may produce synergistic or antagonistic effects in organisms, interacting on the established biomarkers. This study focuses on the interaction on biomarker responses in male goldfish (Carassius auratus) after co-exposure to 17β-estradiol (E2) and benzo(a)pyrene (BaP). Vitellogenin (Vtg), endogenous E2 and ethoxyresorufin-O-deethylase (EROD) were examined to assess the estrogenic effect, steroidogenesis, and metabolism capacity. Exposure to E2 or BaP alone significantly induced the production of Vtg and EROD, respectively. However, these inductions were markedly depressed by the co-exposed chemical, indicative of a reciprocal inhibiting interaction on Vtg and EROD. In addition, the E2-induced steroidogenesis were also suppressed by the coexisting BaP, while the steroidogenesis were not affected by BaP alone. Therefore, our results support a reciprocal inhibiting interaction on the established biomarkers on the estrogenic effect and metabolism capacity, and a one-way inhibition on the steroidogenesis pathway in goldfish after co-exposure to E2 and BaP.
- Copyright
- © 2016, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Zhenhua Yan AU - Guanghua Lu PY - 2016/10 DA - 2016/10 TI - Interaction on biomarkers in goldfish after co-exposure to 17β-estradiol and benzo(a)pyrene BT - Proceedings of the 2016 5th International Conference on Civil, Architectural and Hydraulic Engineering (ICCAHE 2016) PB - Atlantis Press SP - 281 EP - 285 SN - 2352-5401 UR - https://doi.org/10.2991/iccahe-16.2016.49 DO - 10.2991/iccahe-16.2016.49 ID - Yan2016/10 ER -