Proceedings of the 7th International Conference on Biological Science (ICBS 2021)

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Mutation Analysis of PRD-domain of ROR2 and Ig-domain of FLNA in Breast Cancer Development: A Case Study in Malang

Authors
Rizqi Layli Khusufi1, Delia Wahyu Pangesti1, Dwita Novitasari1, Vina Rizkiana1, Reni Krisdayana1, Salsabila Kasta Hygiea Iswara2, Dwi Listyorini1, 2, *
1Department of Biology, Faculty of Mathematic and Natural Sciences, Universitas Negeri Malang
2Department of Biotechnology, Faculty of Mathematic and Natural Sciences, Universitas Negeri Malang, Jl. Semarang No.5, Malang, 65145, Indonesia
*Corresponding author. Email: listyorini.aljabari@um.ac.id
Corresponding Author
Dwi Listyorini
Available Online 2 May 2022.
DOI
10.2991/absr.k.220406.041How to use a DOI?
Keywords
Breast Cancer; ROR2; WNT5A
Abstract

ROR2 is a WNT receptor involved in non-canonical Wnt signaling pathways. PRD and IgFLNA domains are functional domains for binding to downstream proteins that lead to cancer development. This study aimed to analyze mutations in the PRD-IgFLNA-ROR2 domain also the role of the WNT5A-ROR2 pathway involved in the development of breast cancer. The research sample was gDNA of breast cancer tissue provided by Saiful Anwar Regional Public Hospital, East Java, Indonesia. Mutation analysis was conducted using Sanger sequencing. The results of the analysis showed that there were no mutations in the PRD-ROR2 and IgFLNA-ROR2 domains. Based on this study, we suggest that the WNT5A-ROR2 pathway may involve in the incidence of breast cancer in the cases studied. Further analysis is required to give a clear picture of this finding.

Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license.

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Volume Title
Proceedings of the 7th International Conference on Biological Science (ICBS 2021)
Series
Advances in Biological Sciences Research
Publication Date
2 May 2022
ISBN
978-94-6239-573-2
ISSN
2468-5747
DOI
10.2991/absr.k.220406.041How to use a DOI?
Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license.

Cite this article

risenwbib
TY  - CONF
AU  - Rizqi Layli Khusufi
AU  - Delia Wahyu Pangesti
AU  - Dwita Novitasari
AU  - Vina Rizkiana
AU  - Reni Krisdayana
AU  - Salsabila Kasta Hygiea Iswara
AU  - Dwi Listyorini
PY  - 2022
DA  - 2022/05/02
TI  - Mutation Analysis of PRD-domain of ROR2 and Ig-domain of FLNA in Breast Cancer Development: A Case Study in Malang
BT  - Proceedings of the 7th International Conference on Biological Science (ICBS 2021)
PB  - Atlantis Press
SP  - 290
EP  - 296
SN  - 2468-5747
UR  - https://doi.org/10.2991/absr.k.220406.041
DO  - 10.2991/absr.k.220406.041
ID  - Khusufi2022
ER  -