Proceedings of the 7th International Conference on Biological Science (ICBS 2021)

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Pyridinoline and Deoxypyridinoline in Oral Fluids of Menopause Women as Predictor Alveolar Bone Resorption

Authors
Agustin Wulan Suci Dharmayanti1, 2, Hendy Hendarto3, *
1Doctoral Program, Faculty of Medicine, Airlangga University, Surabaya, Jl. Mayjen Prof. Dr. Moestopo 47, Surabaya, Indonesia, 60131
2Biomedical Department, Faculty of Dentistry, Universitas Jember, Jl. Kalimantan 37, Jember, Indonesia, 68121
3Department of Obstetrics and Gynecology, Faculty of Medicine, Airlangga University, Surabaya, Jl. Mayjen Prof. Dr. Moestopo 47, Surabaya, Indonesia, 60131
*Corresponding author. Email: hendy.hendarto@fk.unair.ac.id
Corresponding Author
Hendy Hendarto
Available Online 2 May 2022.
DOI
10.2991/absr.k.220406.070How to use a DOI?
Keywords
Alveolar bone resorption; Deoxypyridinoline; Menopause; Oral fluid; Pyridinoline
Abstract

Menopause presents menstrual cessation that occurs physiologically and is associated with osteoporosis and periodontitis. Osteoporosis and periodontitis are silent diseases that present clinically in the late stage, which alveolar bone resorption causing tooth loss represents both of these disorders. Recently, being developed oral fluids used as predictor diagnostic tools. Pyridinoline and deoxypyridinoline is pyridinium crosslink in collagen arranging bone. Pyridinium crosslink is not re-metabolized in the body and is not influenced by food intake, so it might be a specific predictor of alveolar bone resorption. This study aimed to identify pyridinoline and deoxypyridinoline levels in oral fluids of menopausal women so that they might be used as a specific predictor of alveolar bone resorption. This research was an observational analytic study in which the subjects were menopause women who visited the dental hospital in Universitas Jember. The subjects were assessed their periodontal status and taken the oral fluids (saliva and gingival crevicular fluid). After that, LC-MS/MS analyzed the collected oral fluids. The result showed that although pyridinoline and deoxypyridinoline presented in oral fluids, the pyridinoline level in gingiva crevicular fluid (19.23±9.05) ppm and saliva (30.77±12.82) ppm was lower significantly than the deoxypyridinoline level in gingiva crevicular fluid (70.12 ± 31.01) ppm and saliva (57.48 ± 30.97) ppm. Moreover, there was a relationship between pyridinium crosslink and alveolar bone resorption, except pyridinoline in saliva to alveolar bone loss (r=−0.040 dan p=0.820). Briefly, pyridinoline and deoxypyridinoline presented in oral fluids of menopausal women and might be as the predictor of alveolar bone resorption in menopausal women.

Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license.

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Volume Title
Proceedings of the 7th International Conference on Biological Science (ICBS 2021)
Series
Advances in Biological Sciences Research
Publication Date
2 May 2022
ISBN
978-94-6239-573-2
ISSN
2468-5747
DOI
10.2991/absr.k.220406.070How to use a DOI?
Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license.

Cite this article

risenwbib
TY  - CONF
AU  - Agustin Wulan Suci Dharmayanti
AU  - Hendy Hendarto
PY  - 2022
DA  - 2022/05/02
TI  - Pyridinoline and Deoxypyridinoline in Oral Fluids of Menopause Women as Predictor Alveolar Bone Resorption
BT  - Proceedings of the 7th International Conference on Biological Science (ICBS 2021)
PB  - Atlantis Press
SP  - 498
EP  - 504
SN  - 2468-5747
UR  - https://doi.org/10.2991/absr.k.220406.070
DO  - 10.2991/absr.k.220406.070
ID  - Dharmayanti2022
ER  -