The Potential Effect of Conferment Jamu “Pegal Linu” to Pharmacokinetics of Paracetamol in Wistar Male Rats (Rattus norvegicus L.)

DOI

10.2991/978-94-6463-050-3_5How to use a DOI?

Keywords

Jamu “Pegal Linu”; Paracetamol; Pharmacokinetic Profiles

Abstract

Paracetamol (acetaminophen) is a ubiquitous drug usually prescribed for its analgesic and antipyretic effects. It is a readily available over-the-counter medication. Consumption of jamu and paracetamol causes pharmacokinetic interaction. This study aimed to determine how much the potential of jamu “pegal linu” affected pharmacokinetics profile of paracetamol. Paracetamol levels in rat plasma were analyzed by spectrophotometry UV-Vis using regression and residual methods to primary pharmacokinetic profile: constant absorption rate (Ka), distribution volume (Vd), maximum plasma concentration (Cpmax), Area Under Curve (AUC), and secondary parameter: constant elimination rate (Ke), half-life elimination (t_1/2), maximum concentration (Tmax). Animal subjects were grouped into two categories, group I or paracetamol group (positive control) and group II (paracetamol + jamu “pegal linu”) with three Wistar male rats for each group. The result showed that if jamu “pegal linu” was given, the constant absorption rate (Ka) and elimination rate constant (Ke) were lower, but maximum plasma concentration (Cpmax) and Clearance (Cl) remained steady. Others pharmacokinetics, such as maximum concentration (Tmax), half-life elimination (t_1/2), distribution volume (Vd), and Area Under Curve (AUC), were higher. The bivariate analysis showed no major different (p > 0,05) for both groups. Jamu “pegal linu” co-administration has a potential effect to allegedly the plasma level of paracetamol.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Gilang R. Farizi
AU  - Ovikariani
AU  - Rahmasani
AU  - Any M. Sari
AU  - L. Isti’adzah
PY  - 2022
DA  - 2022/12/14
TI  - The Potential Effect of Conferment Jamu “Pegal Linu” to Pharmacokinetics of Paracetamol in Wistar Male Rats (Rattus norvegicus L.)
BT  - Proceedings of the 4th International Conference Current Breakthrough in Pharmacy (ICB-Pharma 2022)
PB  - Atlantis Press
SP  - 43
EP  - 52
SN  - 2590-3195
UR  - https://doi.org/10.2991/978-94-6463-050-3_5
DO  - 10.2991/978-94-6463-050-3_5
ID  - Farizi2022
ER  -