Proceedings of the 4th International Conference Current Breakthrough in Pharmacy (ICB-Pharma 2022)

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Systematic Review: Anticancer Potential of Active Compounds from Galangal (Alpinia galanga)

Authors
Anugerah Suciati1, *, Maryati1
1Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Jl. A. Yani Tromol Pos I, Pabelan, Kartasura, Sukoharjo, 57162, Indonesia
*Corresponding author. Email: anugerahsuci95@gmail.com
Corresponding Author
Anugerah Suciati
Available Online 14 December 2022.
DOI
10.2991/978-94-6463-050-3_23How to use a DOI?
Keywords
Alpinia galanga; galangal; anticancer; 1’-Acetoxychavicol Acetate; Galangin
Abstract

Galangal (Alpinia galanga) is a plant that is widely spread in Southeast Asia and is widely used for cooking spices. Research related to the effect of A. galanga on cancer cells has been carried out. The purpose of this systematic review is to examine the potential of A. galanga as an anticancer agent and co-chemotherapy. The literature search was carried out through the Pubmed, Science Direct, Springer Link, DOAJ, and Garuda Portal databases. The keywords used were “Alpinia Galanga and Anticancer”, “Alpinia Galanga and Cytotoxicity”, “Lengkuas dan Sitotoksik”, “Lengkuas dan Kanker”, and “Alpinia Galanga and Cancer”. Of the 965 articles found at the beginning of the search, 31 articles were obtained which had been filtered and discussed further. The results showed that the ethanolic extract of A. galanga had a cytotoxic effect because it contained antioxidant polyphenols that inhibited cell proliferation by stopping the cell cycle. The most abundant compounds in A. galanga as anticancer agents are 1'-Acetoxychavicol Acetate (ACA) and Galangin. ACA works to inhibit cancer cells by inducing apoptosis through mitochondrial depolarization and DNA fragmentation in the cell cycle phase. Meanwhile, Galangin works as a chemopreventive agent that reduces oxidative stress and inflammation by suppressing the MAPKs pathway.

Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 4th International Conference Current Breakthrough in Pharmacy (ICB-Pharma 2022)
Series
Atlantis Highlights in Chemistry and Pharmaceutical Sciences
Publication Date
14 December 2022
ISBN
978-94-6463-050-3
ISSN
2590-3195
DOI
10.2991/978-94-6463-050-3_23How to use a DOI?
Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Anugerah Suciati
AU  - Maryati
PY  - 2022
DA  - 2022/12/14
TI  - Systematic Review: Anticancer Potential of Active Compounds from Galangal (Alpinia galanga)
BT  - Proceedings of the 4th International Conference Current Breakthrough in Pharmacy (ICB-Pharma 2022)
PB  - Atlantis Press
SP  - 269
EP  - 282
SN  - 2590-3195
UR  - https://doi.org/10.2991/978-94-6463-050-3_23
DO  - 10.2991/978-94-6463-050-3_23
ID  - Suciati2022
ER  -