Use of Extemporaneous Compounding Products in Pediatric Patients: A Systematic Review

DOI

10.2991/978-94-6463-050-3_10How to use a DOI?

Keywords

“Extemporaneous compounding products”; “Unlicensed”; “Off-label”; “Pediatric”

Abstract

The objective of this study to review and identify recent studies related to incidence of the extemporaneous compounding products used for pediatric patients. This systematic literature review was conducted by searching the literature using the PubMed and Google Scholar electronic databases between 2016 and 2021. The literature results were selected, reviewed, and identified in relation to the incidence of extemporaneous compounding product use, including reporting of off-label and unlicensed drug use in children. Five articles according to the inclusion criteria were identified and evaluated related to reporting of extemporaneous compounding product use. The majority of the findings from several countries such as Indonesia, Vietnam, and Africa disclosed that there was still the use of extemporaneous compounding products and even off-label and unlicensed drugs in pediatric patients with the prevalence from 7.9% to 76.37%. Compared with adult patients, the use of extemporaneous compounding products in children is rather a common practice. The general reason is the limited availability of commercial drugs in the market and the different conditions of pediatric patient individually (age, dose, indication, weight, contraindications) are used as the basis for choosing blended or off-label, or unlicensed drug preparations. For this reason, extemporaneous compounding products remain the first alternative in optimizing therapy for children, regardless of efforts that have been made to develop licensed preparations for children. Demand for extemporaneous compounding product prescriptions will continue to occur among pediatric patients, either by formulating or by manipulating dose and adjusting dose due to the lack of commercial drugs available from the manufacturers, specifically for children. Pharmacists, apart from having significant role in perceiving stability information, compatibility of formulas for extemporaneous drugs, conduct training and education, and appropriate communication are essential to ensure the quality of drugs prescribed to patients so they are safe, effective, and guaranteed.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Zakky Cholisoh
AU  - Ulfa Datrya Fauzi
PY  - 2022
DA  - 2022/12/14
TI  - Use of Extemporaneous Compounding Products in Pediatric Patients: A Systematic Review
BT  - Proceedings of the 4th International Conference Current Breakthrough in Pharmacy (ICB-Pharma 2022)
PB  - Atlantis Press
SP  - 106
EP  - 118
SN  - 2590-3195
UR  - https://doi.org/10.2991/978-94-6463-050-3_10
DO  - 10.2991/978-94-6463-050-3_10
ID  - Cholisoh2022
ER  -