Proceedings of the 4th International Conference Current Breakthrough in Pharmacy (ICB-Pharma 2022)

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Release Profile of Betanin from Chitosan Microparticle Containing Beetroot (Beta vulgaris Linn) Extract

Authors
Anita Sukmawati1, *, Isna V. Risdiyanti1, Clara C. Marthadilla1
1Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Jl. A Yani, Tromol pos 1, Pabelan, Kartasura, Sukoharjo, 57162, Indonesia
*Corresponding author. Email: anita.sukmawati@ums.ac.id
Corresponding Author
Anita Sukmawati
Available Online 14 December 2022.
DOI
10.2991/978-94-6463-050-3_2How to use a DOI?
Keywords
beetroot; chitosan; drug release microparticle
Abstract

Beetroot (Beta vulgaris L.) was formulated into Microparticles (MP) to maintain its antioxidant stability and control the release of active substances for longer use. Chitosan was used as a matrix to encapsulate beetroot extract. This study aims to determine the effect of chitosan concentration on drug loading, encapsulation efficiency, and release profile of betanin from MP containing beetroot extract. Three formulas of microparticles were prepared using the ionic gelation method with concentrations of chitosan 0.5% w/v, 1% w/v, and 2% w/v. Encapsulation efficiency was analyzed using the direct method, and the release profile of the active substance was evaluated using the dissolution method utilizing distilled water as a medium. The results showed that increasing the chitosan concentration from 1 to 2% could reduce the encapsulation efficiency. The release profile of beetroot extract microparticles from chitosan microparticles followed the Higuchi model. The release rate constants of beetroot extract microparticles revealed that using a 2% w/v concentration of chitosan could reduce betanin release rate from beetroot extract microparticles compared to chitosan matrix concentrations of 0.5% w/v and 1% w/v.

Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 4th International Conference Current Breakthrough in Pharmacy (ICB-Pharma 2022)
Series
Atlantis Highlights in Chemistry and Pharmaceutical Sciences
Publication Date
14 December 2022
ISBN
978-94-6463-050-3
ISSN
2590-3195
DOI
10.2991/978-94-6463-050-3_2How to use a DOI?
Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Anita Sukmawati
AU  - Isna V. Risdiyanti
AU  - Clara C. Marthadilla
PY  - 2022
DA  - 2022/12/14
TI  - Release Profile of Betanin from Chitosan Microparticle Containing Beetroot (Beta vulgaris Linn) Extract
BT  - Proceedings of the 4th International Conference Current Breakthrough in Pharmacy (ICB-Pharma 2022)
PB  - Atlantis Press
SP  - 5
EP  - 13
SN  - 2590-3195
UR  - https://doi.org/10.2991/978-94-6463-050-3_2
DO  - 10.2991/978-94-6463-050-3_2
ID  - Sukmawati2022
ER  -