Motif and Pathway Identification with Designing Novel Ligands for Filippi Syndrome

DOI

10.2991/978-94-6463-294-1_20How to use a DOI?

Keywords

ChiP-seq; Molecular Docking; Ligand; computational drug design; phytocompounds

Abstract

Filippi Syndrome is a rare genetic developmental disorder caused by defective mutations in the Cytoskeleton Associated Protein 2 Like (CKAP2L) gene. This disorder manifests with a range of symptoms, including abnormalities in digits and craniofacial features, intellectual disability, and growth retardation, commonly observed in infants. In this study, we focused on the CKAP2L gene associated with Filippi syndrome and performed motif analysis, peak identification, and pathway identification. We employed ChIP sequencing, a technique used to analyze protein-DNA interactions, to obtain high-quality immunoprecipitation ChIP Peaks. The presence of these peaks indicates a high concentration of DNA-binding protein genes. Furthermore, we utilized molecular docking, a computational technique for drug design, to predict the interactions between macromolecules and micro-molecules. Molecular docking is a widely used in-silico structure-based approach in the field of drug development.Overall, our study provides insights into the genetic basis of Filippi Syndrome through analysis of the CKAP2L gene and highlights the potential of molecular docking in computational drug design.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

TY  - CONF
AU  - Swathi Manjunath
AU  - Milan Khandelwal
AU  - I. A. Shylesh Murthy
AU  - Preenon Bagchi
PY  - 2023
DA  - 2023/11/17
TI  - Motif and Pathway Identification with Designing Novel Ligands for Filippi Syndrome
BT  - Proceedings of the International Conference on Advances in Nano-Neuro-Bio-Quantum (ICAN 2023)
PB  - Atlantis Press
SP  - 256
EP  - 264
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-294-1_20
DO  - 10.2991/978-94-6463-294-1_20
ID  - Manjunath2023
ER  -