An Electrochemical Sensor for Prothrombin-Time Test

DOI

10.2991/icammce-18.2018.3How to use a DOI?

Keywords

PT testing; microfluidic chip; POCT

Abstract

As a new interdisciplinary, blood coagulation and thrombosis, being involved in the development and progression of many diseases, have a prominent clinical significance. Prothrombin time (PT time) is the time when calcium and tissue factor is added into the blood sample until when the blood sample completely clots. Clinically, PT time is an extremely sensitive screening index in coagulation system, it has an irreplaceable influence to patients’ daily medication and related treatments as it can primarily reflect the normality of the extrinsic coagulation. Until recently, most automated coagulation analyzers used in hospitals can detect a variety of samples and projects at the same time with high accuracy. However it could only be operated by the professionals, not to mention the high production and testing costs. For these reasons, the frequency and ease-of-operation of the detection have been limited. In order to develop a real-time and household detection method, paper-chips and POCT technology are mainly utilized in this work. Paper-chips possesses their own advantages, as it can easily reflect the blood clotting process by detecting a change in the conductance of blood during the blood coagulation process. After a series of design, tests and improvements, a chip for PT time testing is fabricated. Using this chip, the PT time of several blood samples are tested, and the testing results confirmed that the further improved chip can complete the measurement and correction of blood PT time test. Compared with conventional coagulation analyzer, paper-chips have several intrinsic advantages such as reduced cost, higher accuracy, and better application in POCT use. We believe that pushing the further experimental products to market could fill the vacancy in the domestic industry.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Lifei Xin
AU  - Hong Liu
PY  - 2018/05
DA  - 2018/05
TI  - An Electrochemical Sensor for Prothrombin-Time Test
BT  - Proceedings of the 2018 3rd International Conference on Advances in Materials, Mechatronics and Civil Engineering (ICAMMCE 2018)
PB  - Atlantis Press
SP  - 11
EP  - 17
SN  - 2352-5401
UR  - https://doi.org/10.2991/icammce-18.2018.3
DO  - 10.2991/icammce-18.2018.3
ID  - Xin2018/05
ER  -