Estrogenic Joint Effect of BPA and DES on MCF-7 Cells

DOI

10.2991/icamcs-16.2016.181How to use a DOI?

Keywords

BPA, DES, estrogenic effect, joint effect, breast cancer cells

Abstract

Nowadays environmental health problems caused by Endocrine disrupting chemicals (EDCs) really attracted much concern. Bisphenol A (BPA) and diethylstilbestrol (DES), synthetic estrogens that have similar structure, were proved to be related to various type of cancers, including breast cancer. In this paper, cell viability assay was used as evaluation basis to examine the estrogenic effect and joint effect of BPA, DES and 17 -estradiol (E2). The result showed that the proliferation of MCF-7 cells was promoted by environmental relevant doses of BPA and DES. And the more intense effect would be realized when combining BPA with DES. In addition, BPA or DES could strengthen the estrogenic effect of E2. However, for ternary mixture of E2, BPA and DES, all the experimental groups performed an antagonism.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Hongping Pu
AU  - Xiaodong Ma
AU  - Zhixiang Xu
AU  - Jun Liu
AU  - Bin Huang
AU  - Dong Ren
AU  - Huan He
AU  - Xuejun Pan
PY  - 2016/06
DA  - 2016/06
TI  - Estrogenic Joint Effect of BPA and DES on MCF-7 Cells
BT  - Proceedings of the 2016 5th International Conference on Advanced Materials and Computer Science
PB  - Atlantis Press
SP  - 890
EP  - 894
SN  - 2352-5401
UR  - https://doi.org/10.2991/icamcs-16.2016.181
DO  - 10.2991/icamcs-16.2016.181
ID  - Pu2016/06
ER  -