Experimental Study on the Improvement of Schisandra and Epimedium Extract on the Memory Ability in Mice

DOI

10.2991/icaees-15.2015.201How to use a DOI?

Keywords

Schisandra; Epimedium; Memory; MDA; SOD.

Abstract

To observe the improvement of Schisandra and Epimedium extract (WY) on the memory ability in mice. Methods: ICR male mice were randomly divided into control group, low-, medium- and high-dose WY groups. The mice were intragastrically given the same volume of distilled water, 300 mg/kg WY, 600 mg/kg WY, and 1200 mg/kg WY one time daily for 28 days, respectively. On the first day after the administration, the step-down test were performed to observe the learning and memory ability of mice; moreover, SOD activities and MDA contents in brain tissues of the mice were further detected to explore the underlying mechanisms of effects of WY on the mice’s memory ability. Results: Compared with those in the blank control group, the memory ability of mice in WY-treated groups were significantly improved, and the content of MDA was decreased and SOD activity was increased in WY-treated groups (p<0.05). Conclusion: WY can improve the mice’s memory ability .

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Jiahong Li
AU  - Chunmei Wang
AU  - Bing Li
AU  - Jinghui Sun
AU  - Weijing Sun
PY  - 2015/07
DA  - 2015/07
TI  - Experimental Study on the Improvement of Schisandra and Epimedium Extract on the Memory Ability in Mice
BT  - Proceedings of the 3rd International Conference on Advances in Energy and Environmental Science 2015
PB  - Atlantis Press
SP  - 1092
EP  - 1095
SN  - 2352-5401
UR  - https://doi.org/10.2991/icaees-15.2015.201
DO  - 10.2991/icaees-15.2015.201
ID  - Li2015/07
ER  -