Control Mechanism Analysis of Bone Remodelling under Mechanical Stimuli

DOI

10.2991/icadme-15.2015.393How to use a DOI?

Keywords

bone remodelling, control mechanism, mechanical stimuli

Abstract

In this paper the control mechanism of bone remodelling under mechanical stimuli at cellular level is investigated by means of an extensive parametric study on a theoretical model developed previously. From a perspective of control mechanism, it is found that there are several control mechanisms working simultaneously in bone remodelling which is a complex process. To this purpose, an extensive parametric study has been carried out for investigating model parameter space related to cell differentiation and apoptosis which can describe the fundamental cell lineage behaviors. After analyzing all the combinations of 728 permutations in six model parameters, we have identified a small number of parameter combinations that can lead to physiologically realistic responses which are similar to theoretically idealized physiological responses. The results presented in the work enhanced our understanding on mechanical bone remodelling and the identified control mechanisms can help researchers to develop combined pharmacological-mechanical therapies to treat bone loss diseases such as osteoporosis.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Yanan Wang
AU  - Huaiwen Wang
PY  - 2015/10
DA  - 2015/10
TI  - Control Mechanism Analysis of Bone Remodelling under Mechanical Stimuli
BT  - Proceedings of the 5th International Conference on Advanced Design and Manufacturing Engineering
PB  - Atlantis Press
SP  - 2103
EP  - 2107
SN  - 2352-5401
UR  - https://doi.org/10.2991/icadme-15.2015.393
DO  - 10.2991/icadme-15.2015.393
ID  - Wang2015/10
ER  -