Proceedings of the 3rd International Conference on Material, Mechanical and Manufacturing Engineering

Anti-hepatocarcinoma effects of chrysin loaded solid lipid nanoparticle against H22 tumor bearing mice

Authors
Zhiping Wang, Hua Fan, Yan Li, Yifei Wang
Corresponding Author
Zhiping Wang
Available Online August 2015.
DOI
10.2991/ic3me-15.2015.197How to use a DOI?
Keywords
solid lipid nanoparticles; Chrysin; Cytotoxicity; Antitumor activity; H22 cells; tumor bearing mice
Abstract

Hepatocarcinoma, a malignant cancer, threaten human life badly. It is a current issue to seek the effective natural remedy from plant to treat cancer due to the resistance of the advanced hepatocarcinoma to chemotherapy. Chrysin (Chr), a major symbol ingredient in Chinese Propolis, has a wide range of pharmacological properties and is considered to have anti-hepatocarcinoma effects. However its low oral bioavailability restricts its wide application. In this report, Chr-loaded solid lipid nanoparticles (Chr-SLN) composed of Chr, cremophor EL and glyceryl behenate were prepared by high pressure homogenization technique. The in vivo anti-hepatocarcinoma effects of Chr-SLN relative to efficacy of bulk Chr were evaluated. The particle size and zeta potential of Chr-SLN were 479.7 nm and 26.3 mV, respectively. The results showed higher antitumor efficacy against H22 solid tumor bearing mice. These results suggest that the delivery of Chr-SLN is a promising approach for treating tumors.

Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 3rd International Conference on Material, Mechanical and Manufacturing Engineering
Series
Advances in Engineering Research
Publication Date
August 2015
ISBN
978-94-6252-100-1
ISSN
2352-5401
DOI
10.2991/ic3me-15.2015.197How to use a DOI?
Copyright
© 2015, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Zhiping Wang
AU  - Hua Fan
AU  - Yan Li
AU  - Yifei Wang
PY  - 2015/08
DA  - 2015/08
TI  - Anti-hepatocarcinoma effects of chrysin loaded solid lipid nanoparticle against H22 tumor bearing mice
BT  - Proceedings of the 3rd International Conference on Material, Mechanical and Manufacturing Engineering
PB  - Atlantis Press
SP  - 1020
EP  - 1024
SN  - 2352-5401
UR  - https://doi.org/10.2991/ic3me-15.2015.197
DO  - 10.2991/ic3me-15.2015.197
ID  - Wang2015/08
ER  -