Synthesis of Quinazolinyl Chalcone Derivatives

DOI

10.2991/ic3me-15.2015.61How to use a DOI?

Keywords

2-aminobenzonitrile; N,N-dimethylformamide dimethyl acetal; aminoa- cetophenone; paradimethylaminobenzaldehyde; chalcone; quinazoline

Abstract

4-(4'-quinazolin-ylamino) phenyl-4-(N,N- dimethylamino) phenyl propenyl ketone with total yield of 68.0% was synthesized with 2-aminobenzonitrile and N,N-dimethylformamide dimethyl acetal as a starting material, the synthesis of N-(2-cyanophenyl)-N,N-dimethyl formami- dine, and then amino acetophenone to form a ring, and finally reaction with formaldehyde dimethylaminobenzaldehyde. The experimental conditions were optimized. The results showed that: Intermediate 1 was synthesized by 2-aminobenzonitrile and N, N- dimethylformamide dimethyl acetal and their molar ratio of 1: 2, the optimal reaction temperature is 85 . Intermediate 2 synthesized optimal temperature of 105 . Intermediates and target compounds by 1H NMR, 13C NMR and mass spectrometry for structural characterization.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Heping Yan
AU  - Jianguang Shi
AU  - Gaozhang Gou
AU  - Jucheng Zhang
AU  - Dushu Huang
AU  - Shijuan Xu
AU  - Xuebin Chen
AU  - Xuequan Wang
AU  - Yong Hong
AU  - Wei Liu
PY  - 2015/08
DA  - 2015/08
TI  - Synthesis of Quinazolinyl Chalcone Derivatives
BT  - Proceedings of the 3rd International Conference on Material, Mechanical and Manufacturing Engineering
PB  - Atlantis Press
SP  - 320
EP  - 324
SN  - 2352-5401
UR  - https://doi.org/10.2991/ic3me-15.2015.61
DO  - 10.2991/ic3me-15.2015.61
ID  - Yan2015/08
ER  -