Immunoexpression of Interleukin-6 (Il-6) in Keloid

DOI

10.2991/978-2-38476-110-4_104How to use a DOI?

Keywords

Immunoexpression; Interleukin-6; Keloid

Abstract

The characteristics of keloid disease are characterized by excessive accumulation of collagen in the dermis and subcutaneous tissue due to damage to skin tissue. This condition causes various complex problems such as loss of self-confidence, low self-esteem, shyness accompanied by obvious physical damage such as contractures, pain, itching and lack of range of motion. Various studies have investigated the genes responsible for this condition including the interleukin (IL)-6 gene. IL-6 is a pleiotropic cytokine with multiple biological functions. Naturally, these cytokines are produced locally upon intense and sustained damage and initiate transcriptional provocative reactions via the IL-6 alpha receptor. The purpose of this study was to analyze Interleukin-6 immunoexpression in keloids. This research is an observational study with a cross sectional research design. Samples were stored in formalin-fixed and paraffin-embedded (FFPE) material which was diagnosed histopathologically as a keloid disease. The research variable to be examined is IL-6 immunoexpression. The examination technique used is immunohistochemical examination. There were 31 cases of keloids, aged between 16 and 47 years, mostly in women (67.7%), occurring in the trunk area (70.9%) 18 cases of recurrence (58%). We found 24 cases (77.4%) with strong IL-6 immunoexpression in fibroblast cells. There were 7 cases (22.6%) with weak immunoexpression. There was a strong correlation between IL-6 immunoexpression and age (p=0.04) and recurrence (p=0.02). There is no significant relationship with gender. Fibroblasts produce collagen and fibronectin which are necessary for wound re-epithelialization. Remodeling of these deposits and matrices is a continuous process and is influenced by various growth factors. IL-6 cytokine is produced more by dermal than superficial fibroblasts, this is what determines the difference between deep and superficial wound healing. This can be considered as regulatory factor IL-6 in keloid disease.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Fairuz
AU  - Humaryanto
PY  - 2023
DA  - 2023/11/07
TI  - Immunoexpression of Interleukin-6 (Il-6) in Keloid
BT  - Proceedings of the 4th Green Development International Conference (GDIC 2022)
PB  - Atlantis Press
SP  - 1081
EP  - 1087
SN  - 2352-5398
UR  - https://doi.org/10.2991/978-2-38476-110-4_104
DO  - 10.2991/978-2-38476-110-4_104
ID  - 2023
ER  -