Construction of Gene Network in Type 2 Diabetes with Genome-Wide Association Study

DOI

10.2991/emim-17.2017.319How to use a DOI?

Keywords

Diabetes mellitus; Type 2; Gene network; Pathway

Abstract

A genome-wide association analysis (GWAS) based on the research results, the local gene networks a preliminary establishment of susceptibility genes of type 2 diabetes mellitus, for future gene-gene interactions, provides reference for the research on gene environment interaction. 65 candidate genes selected from the study by GWAS of susceptibility genes of type 2 Diabetes Association, it selects 2 or more pathways target genes from 27, and through the selection of screening, intermediate gene pathway, construct local gene network, and use Ai CS6 software to draw network diagram. It consists of the following steps: (1) building a network of basic information of genes and pathways obtained by the KEGG and Genecards database; (2) establish a primary gene network; (3) selecting the middle gene; (4) the gene level two connection; (5) construction and mapping network local gene network. A total of 1 genes including the gene and a number of intermediate genes, as well as a series of linked genes and intermediate molecules, were obtained. The network contains 20 biological pathways. Local gene network conclusion this study obtained a more intuitive and comprehensive display of beta cell dysfunction and insulin resistance in susceptible relationship between genes, which can provide reference for study of molecular pathogenesis of type 2 diabetes in depth.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Ming Zheng
AU  - Mugui Zhuo
PY  - 2017/04
DA  - 2017/04
TI  - Construction of Gene Network in Type 2 Diabetes with Genome-Wide Association Study
BT  - Proceedings of the 7th International Conference on Education, Management, Information and Mechanical Engineering (EMIM 2017)
PB  - Atlantis Press
SP  - 1578
EP  - 1581
SN  - 2352-538X
UR  - https://doi.org/10.2991/emim-17.2017.319
DO  - 10.2991/emim-17.2017.319
ID  - Zheng2017/04
ER  -