Synthesis of 5-(4-Morpholino-7, 8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl)pyridin-2-amine
Authors
Ping Wang, Chengyu Sun, Yueyue Xiao, Chen Chen, Zhenhua Chen, Wufu Zhu
Corresponding Author
Ping Wang
Available Online April 2015.
- DOI
- 10.2991/emim-15.2015.168How to use a DOI?
- Keywords
- Thiopyrano[4;3-d]pyrimidine; Morpholine; Synthesis; Anticancer; Inhibitors
- Abstract
A novel thiopyrano[4,3-d]pyrimidine derivative compound 1 was synthesized with methyl dimethyl 3,3'-thiodipropionate as starting material through five steps, including cyclization, chlorination, substitution with morpholine and coupling with 5-bromopyridin-2-amine through Suzuki reaction. And its structure was confirmed by 1H NMR and MS. The total yield of the five steps was 18.6% (calculated from methyl dimethyl 3,3'-thiodipropionate).Compound 1 is an important intermediate in the design and synthesis of thiopyrano[4,3-d]pyrimidine derivatives small molecule inhibitors.Therefore, the synthesis of Compound 1 has an important significance in the the study of anticancer drugs.
- Copyright
- © 2015, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Ping Wang AU - Chengyu Sun AU - Yueyue Xiao AU - Chen Chen AU - Zhenhua Chen AU - Wufu Zhu PY - 2015/04 DA - 2015/04 TI - Synthesis of 5-(4-Morpholino-7, 8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-yl)pyridin-2-amine BT - Proceedings of the 2015 International Conference on Education, Management, Information and Medicine PB - Atlantis Press SP - 863 EP - 866 SN - 2352-5428 UR - https://doi.org/10.2991/emim-15.2015.168 DO - 10.2991/emim-15.2015.168 ID - Wang2015/04 ER -