Lipase-Catalyzed Synthesis of S-Naproxenal oleins

DOI

10.2991/emim-15.2015.46How to use a DOI?

Keywords

Naproxen; Naproxenal oleins; Prodrugs; Trolein; Transesterification.

Abstract

S-Naproxenal oleins are compounds of S-Naproxen ((S)-2-(6-methoxy–2-naphthyl) propionic acid) and olein connected by an ester bond and can be used as potential prodrug in anti-inflammatory. In the present work, we describe for the first time the lipase-catalyzed synthesis of the S-Naproxenal oleins by transesterification between S-Naproxen and triolein in organic solvents medium. The ability of lipases to catalyze the transesterification between S-Naproxen and triolein was investigated. Only the lipase from Candida rugosa and the immobilized lipase B from Candida antarctica (Novozym 435) catalyzed the transesterification. The influences of reaction condition on the combined yield of S-Naproxenal diolein (NDO) and S-Naproxenal monoolein (NMO) were investigated. Water activity (aw) had an obvious influence on transesterification efficacy. A maximal combined yield of 23.1 % of S-Naproxenal diolein (NDO) and S-Naproxenal monoolein (NMO) was obtained under optimum condition. These results indicated the industrial potential of the operation scheme developed in this study.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Jiaying Xin
AU  - Jiawen Jiang
PY  - 2015/04
DA  - 2015/04
TI  - Lipase-Catalyzed Synthesis of S-Naproxenal oleins
BT  - Proceedings of the 2015 International Conference on Education, Management, Information and Medicine
PB  - Atlantis Press
SP  - 236
EP  - 239
SN  - 2352-5428
UR  - https://doi.org/10.2991/emim-15.2015.46
DO  - 10.2991/emim-15.2015.46
ID  - Xin2015/04
ER  -