Synthesis of 2-Chloronicotinic Acid Derivatives

DOI

10.2991/emcm-16.2017.119How to use a DOI?

Keywords

2-Chloronicotinic acid; 2-Morpholinonicotinic acid; Synthesis

Abstract

2-Chloronicotinic acid and its derivatives are important intermediates for the synthesis of medical antibiotics, anti-cardiovascular drugs, insecticides and herbicides, and they used in the synthesis pranoprofen and diflufenican. In this work, a rapid synthetic method for 2-morpholinonicotinic acid was established. The 2-morpholinonicotinic acid was synthesized from the commercially available 2-chloronicotinic acid through three steps including esterification, nucleophilic substitution and hydrolysis. The structures were confirmed by MS. Furthermore, the synthetic method was optimized, and the total yield of the three steps was 93 %.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Bingbing Zhao
AU  - Zhou Lan
AU  - Shan Xu
AU  - Yinghua Xiong
PY  - 2017/02
DA  - 2017/02
TI  - Synthesis of 2-Chloronicotinic Acid Derivatives
BT  - Proceedings of the 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
PB  - Atlantis Press
SN  - 2352-538X
UR  - https://doi.org/10.2991/emcm-16.2017.119
DO  - 10.2991/emcm-16.2017.119
ID  - Zhao2017/02
ER  -