Synthesis of 3-phenyl-1H-pyrazole Derivatives

DOI

10.2991/emcm-16.2017.117How to use a DOI?

Keywords

3-Phenyl-1H-pyrazole; Synthesis; Acetophenone

Abstract

3-phenyl-1H-pyrazole (1) is an important intermediate for the synthesis of many biologically active compounds. It was synthesized from acetophenone (2) and hydrazine through two steps including Knoevenagel condensation, Cyclization reaction reaction. In this paper, three novel 3-phenyl-1H-pyrazole derivatives were prepared. The structure were confirmed by MS and 1H NMR. Furthermore, the synthetic method was optimized. The total yield of the two steps were 80%.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Xiaobo Liu
AU  - Shan Xu
AU  - Yinhua Xiong
PY  - 2017/02
DA  - 2017/02
TI  - Synthesis of 3-phenyl-1H-pyrazole Derivatives
BT  - Proceedings of the 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
PB  - Atlantis Press
SN  - 2352-538X
UR  - https://doi.org/10.2991/emcm-16.2017.117
DO  - 10.2991/emcm-16.2017.117
ID  - Liu2017/02
ER  -