Synthesis of 1-(2-(piperidin-1-yl)ethyl)-1H-pyrrole-2-carbaldehyde

DOI

10.2991/emcm-16.2017.114How to use a DOI?

Keywords

1H-pyrrole-2-carbaldehyde; Synthesis

Abstract

1-(2-(piperidin-1-yl)ethyl)-1H-pyrrole-2-carbaldehyde 4a-b is a new aqueous solubility aldehyde as an important intermediates of small molecule anticancer drugs. In this work, a rapid synthetic method for target compounds 4a-b was established. The compound 4a-b was synthesized from the commercially available pyrrole through three steps including acylation and two steps nucleophilic substitution. The structure was confirmed by MS and 1HNMR. Furthermore, the synthetic method was optimized. The total yield of the three steps was 65%

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Caolin Wang
AU  - Yuanbiao Tu
AU  - Jiaqian Han
AU  - Yuping Guo
PY  - 2017/02
DA  - 2017/02
TI  - Synthesis of 1-(2-(piperidin-1-yl)ethyl)-1H-pyrrole-2-carbaldehyde
BT  - Proceedings of the 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
PB  - Atlantis Press
SN  - 2352-538X
UR  - https://doi.org/10.2991/emcm-16.2017.114
DO  - 10.2991/emcm-16.2017.114
ID  - Wang2017/02
ER  -