Synthesis of 2 - ((4-Substituted Phenyl) Amino) Benzaldehyde

DOI

10.2991/emcm-16.2017.109How to use a DOI?

Keywords

2-((4-substituted phenyl) amino) benzaldehyde; Synthesis; Process optimization

Abstract

2-((4-substituted phenyl) amino) benzaldehyde, is an important intermediate for the synthesis of many biologically active intermediates of anticancer drugs. In this work, a rapid and high efficiency synthetic method for compound 1a-1b was established. Compound 1a-1b was synthesized from 2-chloronicotinic acid and 4-substituted anilines through three steps including nucleophilic substitution, reduction and oxidation reaction. The structure of the target compound 1a-1b was confirmed by H NMR and MS spectrum. Furthermore, the synthetic method was optimized. The total yield of the three steps was 59.49%.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Yongli Duan
AU  - Zhimin Li
AU  - Qidong Tang
AU  - Rui Li
AU  - Shan Xu
PY  - 2017/02
DA  - 2017/02
TI  - Synthesis of 2 - ((4-Substituted Phenyl) Amino) Benzaldehyde
BT  - Proceedings of the 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
PB  - Atlantis Press
SN  - 2352-538X
UR  - https://doi.org/10.2991/emcm-16.2017.109
DO  - 10.2991/emcm-16.2017.109
ID  - Duan2017/02
ER  -