Synthesis of 4-chloro-6-methoxy-2-methyl-3-nitroquinoline

DOI

10.2991/emcm-16.2017.104How to use a DOI?

Keywords

4-Chloro-6-methoxy-2-methyl-3-nitroquinoline; PI3K/mTOR inhibitor; Synthesis

Abstract

4-Chloro-6-methoxy-2-methyl-3-nitroquinoline (1) was synthesized from 4-methoxyaniline through three steps including Cyclization, Nitrification and Chlorination. The structure of the target product (1) was confirmed by 1H NMR and MS. This method started with cheap raw materials was of simple experimental operation and mild reaction conditions. It was suitable for large scale pilot study and the yield of the product is achieved to 85%.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Lei Zhao
AU  - Fei Lei
AU  - Yuping Guo
PY  - 2017/02
DA  - 2017/02
TI  - Synthesis of 4-chloro-6-methoxy-2-methyl-3-nitroquinoline
BT  - Proceedings of the 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
PB  - Atlantis Press
SN  - 2352-538X
UR  - https://doi.org/10.2991/emcm-16.2017.104
DO  - 10.2991/emcm-16.2017.104
ID  - Zhao2017/02
ER  -