One-Pot Synthesis of 1, 4-Dihydropyridines in PEG Under Catalyst-Free Conditions

DOI

10.2991/cmfe-15.2015.82How to use a DOI?

Keywords

1,4-Dihydropyridines, Hantzsch reaction, Multicomponent synthesis, PEG400, Catalyst free.

Abstract

A simple, inexpensive, and efficient one-pot synthesis of 1,4-dihydropyridine via Hantzsch reaction was achieved in good to excellent yields under catalyst free conditions by using PEG400 as solvent. In this reaction, PEG-400 was used as the solvent, which has such advantages: absolutely nontoxic, inexpensive, thermally stable, recoverable and easy to dispose in the reaction. And the corresponding products: 1,4-Dihydropyridine derivatives are very important in organic chemistry and medicine industry, by the using of PEG, the yields of the reaction were all very high(most above 95%). Finally, as to the inexpensive of PEG-400 and the high yields of the reaction, also because of the easy-treated procedures, this kind of reaction could be easier to produce in industrial. So, Polyethylene glycol offers a convenient, inexpensive, non-ionic liquid, non-toxic and recyclable reactions .

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Jing Lv
AU  - Liang Jun
AU  - Xiangfeng Kong
AU  - Lu Cao
AU  - Ying Zhang
AU  - Shuwei Zhang
PY  - 2015/07
DA  - 2015/07
TI  - One-Pot Synthesis of 1, 4-Dihydropyridines in PEG Under Catalyst-Free Conditions
BT  - Proceedings of the International Conference on Chemical, Material and Food Engineering
PB  - Atlantis Press
SP  - 343
EP  - 346
SN  - 2352-5401
UR  - https://doi.org/10.2991/cmfe-15.2015.82
DO  - 10.2991/cmfe-15.2015.82
ID  - Lv2015/07
ER  -