Proceedings of the 2022 International Conference on Creative Industry and Knowledge Economy (CIKE 2022)

Research on the Pros and Cons of the Mouse Model of Alzheimer’s Disease

Authors
Manke Cai
Zhongshan College of Dalian Medical University
*Corresponding author. Email: 510303610@qq.com
Corresponding Author
Manke Cai
Available Online 18 April 2022.
DOI
10.2991/aebmr.k.220404.056How to use a DOI?
Keywords
Alzheimer’s disease; Mouse model; Generation; Over-expression; Transgenic; Knock-in
Abstract

Alzheimer’s disease (AD) is the biggest cause of dementia, and the animal model has always been a high research priority in treating AD. This paper introduces three generations of AD mouse models by summarizing their merits and limitations in order to facilitate the understanding of these animal models and design more precise experiments in the future. Conclusions can be drawn that the over-expression paradigm of the first generation may cause extra phenotypes which are unrelated to AD, while the second generation overcame this problem but it is still unsuitable to be used in preclinical immunotherapy studies because of the discrete affinity for anti-Aβ antibodies. Finally, the third generation was introduced to the community. Without the Arctic mutation, this generation could also accumulate wild-type human Aβ quickly.

Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license.

Download article (PDF)

Volume Title
Proceedings of the 2022 International Conference on Creative Industry and Knowledge Economy (CIKE 2022)
Series
Advances in Economics, Business and Management Research
Publication Date
18 April 2022
ISBN
978-94-6239-565-7
ISSN
2352-5428
DOI
10.2991/aebmr.k.220404.056How to use a DOI?
Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license.

Cite this article

TY  - CONF
AU  - Manke Cai
PY  - 2022
DA  - 2022/04/18
TI  - Research on the Pros and Cons of the Mouse Model of Alzheimer’s Disease
BT  - Proceedings of the 2022 International Conference on Creative Industry and Knowledge Economy (CIKE 2022)
PB  - Atlantis Press
SP  - 300
EP  - 304
SN  - 2352-5428
UR  - https://doi.org/10.2991/aebmr.k.220404.056
DO  - 10.2991/aebmr.k.220404.056
ID  - Cai2022
ER  -