Evaluation Nano-Phytosome of Myricetin with Thin Layer Film Hydration-Sonication Method

DOI

10.2991/ahsr.k.200523.070How to use a DOI?

Keywords

nano-phytosome, myricetin, thin layer film hydration

Abstract

Nano-phytosome is a nano technology that’s use to improve the bioavailability of active compound in plants by binding with phospholipids which have similar characteristic with cell membranes. In this study, Myricetin is the main ingredient that we used in nano-phytosome formulation. Myrisetin is a natural flavonoid compound with antioxidant activitiy and has low bioavailability and permeability values. The purpose of this study is to knowing characterization nano-phytosomes of myricetin. Nano-phytosomes is made using thin-sonication hydration method with a variation ratio of myrisetin: phosphatidylcholine: cholesterol 1: 1: 0.4 (F1), 1: 2: 0.4 (F2) and 1: 3: 0.4 (F3). Characterization of nano-phytosome includes particle size, polydispers index, stability, adsorption efficiency and antioxidant activity. The results showed that particle size in F1, F2 and F3 were 233.6 nm, 250.0 nm, and 242.7 nm with polydispersion indexes were 0.260, 0.260 and 0.447, respectively. Potential zeta values (F1) -21.7 mV, (F2) -15.7 mV and (F3) -11.3 mV. Entrapment efficiency (F1) 91.94%, (F2) 91.39% and (F3) 91.39%. The antioxidant activity of the formulas have values (F1) 41,13 ppm; (F2) 25.46 ppm; and (F3) 20.64 ppm. Based on the evaluation results, that the more the concentration of phosphatidylcholine added, the more particle size, polydispersion index, adsorption efficiency and antioxidant activity were increases.

Copyright

© 2020, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Yuli Edy Saputra
AU  - Muhammad Dzakwan
AU  - Nur Aini Dewi
PY  - 2020
DA  - 2020/06/08
TI  - Evaluation Nano-Phytosome of Myricetin with Thin Layer Film Hydration-Sonication Method
BT  - The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019)
PB  - Atlantis Press
SP  - 294
EP  - 297
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.200523.070
DO  - 10.2991/ahsr.k.200523.070
ID  - Saputra2020
ER  -