Analgesic Activity of Infusion of Beluntas Radix (Pluchea indica (L.)) on the Male Mice

DOI

10.2991/ahsr.k.200523.062How to use a DOI?

Keywords

radix, Pluchea indica L, infusion, analgesic, writhing method

Abstract

Objectives: The study aims to determine the analgesic activity of beluntas radix infusion. Method: The research used 25 of male mice. The mice were divided into five groups, which are negative control, positive control, and three testing groups (in different doses). Fifteen minutes after infusion of beluntas radix per oral, the mice were given the acetic acid 0.7% i.p. The cumulative writhe was calculated in every 5 minutes for one hour and was counted for the protection and the effectivity percentage. Results and Discussions: Beluntas radix infusion of doses 9.75 mg/20 g, 19.5 mg/20 g and 29.25 mg/20 g of body weight decreased the writhing responses significantly (p<0.05) compared with the control. Each doses gave the protection percentage 55.8%, 64.2% and 77.5% and the effectivity percentage 113.4%, 130.5% and 157.5%. Conclusion: Analgesic activity of beluntas radix infusion is influenced by dose level. Test dose III (29.25 mg / 20 g BW of mice) has the best activity.

Copyright

© 2020, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Hendy Suhendy
AU  - Muharam Priatna
AU  - Yoppi Iskandar
PY  - 2020
DA  - 2020/06/08
TI  - Analgesic Activity of Infusion of Beluntas Radix (Pluchea indica (L.)) on the Male Mice
BT  - The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019)
PB  - Atlantis Press
SP  - 258
EP  - 260
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.200523.062
DO  - 10.2991/ahsr.k.200523.062
ID  - Suhendy2020
ER  -