A Better Characterization of Brain Damage in Carbon Monoxide Intoxication Assessed in Vivo Using Diffusion Kurtosis Imaging

DOI

10.2991/bst-16.2016.39How to use a DOI?

Keywords

Carbon monoxide poisoning, Diffusion kurtosis imaging.

Abstract

Diffusion kurtosis imaging findings in delayed encephalopathy after acute carbon monoxide poisoning have seldom reported. We present a study of a 25 -year-old female with acute carbon monoxide poisoning by using conventional magnetic resonance imaging (MRI) and diffusion kurtosis imaging (DKI). Conventional brain MR imaging on day-6 after Carbon monoxide (CO) poisoning showed hyperintensities in the bilateral temporal lobe, hippocampus and basal ganglia in T2-weighted imaging. Compared with the healthy age-matched control group (n=5), in day-16, the values measured in the patient on DKI showed MD values were significantly increased and FA values were decreased in the cerebellum (p<0.05, all), MK values were increased in the basal ganglia (p<0.05). On week-20, FA values decreased and MD values increased in the basal ganglia (p<0.05). MK values decreased in the basal ganglia but with no statistical significance. MRI showed only abnormal hyperintensities remained in the basal ganglia on T2WI. As sensitive imaging techniques, DKI can provide a more comprehensive characterization of damage in patients after acute carbon monoxide poisoning, and provide additional and complementary information to DTI on pathophysiology. A higher MK value of the lesion in early stage may strongly suggest the poor prognosis of carbon monoxide poisoning.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Wen-Yao Fan
AU  - Wen-Bin Zheng
AU  - Xi-Ran Chen
PY  - 2016/01
DA  - 2016/01
TI  - A Better Characterization of Brain Damage in Carbon Monoxide Intoxication Assessed in Vivo Using Diffusion Kurtosis Imaging
BT  - Proceedings of the 2016 International Conference on Biological Sciences and Technology
PB  - Atlantis Press
SP  - 263
EP  - 269
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-16.2016.39
DO  - 10.2991/bst-16.2016.39
ID  - Fan2016/01
ER  -