Reinstatement of Cue-induced Methamphetamine-seeking Behaviour

DOI

10.2991/bme-15.2015.8How to use a DOI?

Keywords

Methamphetamine, Self-administration, Relapse, Cue-induced, extinction, Animal model

Abstract

Abstract. Cue-induced methamphetamine (METH) craving increases after prolonged forced abstinence from METH. In the present study, we employed male Sprague-Dawley rats to study METH reinstatement behavior induced by conditioned cue. We trained rats to self-administer METH under a fixed ratio 1 schedule for 10 sessions (4 hours/day), and then assessed METH induced by conditioned cues after 12 d extinction. Under both training and extinction conditions, the animals showed increased responding of nose poking on cue-induced during the period reinstatement. The results suggested that self-administration responding could be reinitiated by cue-induced from the drug environment in rats. The procedure used in this model may be useful for the study of the underlying mechanism of cue-induced reinstatement.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Baomiao Ma
AU  - Kai Yue
AU  - Junqiao Xing
AU  - Xiaokang Gong
AU  - Lin Chen
AU  - Qin Ru
AU  - Qi Xiong
AU  - Xiang Tian
AU  - Rihui Wu
AU  - Yongping Gan
AU  - Daisong Wang
PY  - 2015/09
DA  - 2015/09
TI  - Reinstatement of Cue-induced Methamphetamine-seeking Behaviour
BT  - Proceedings of the 2015 International Forum on Bioinformatics and Medical Engineering
PB  - Atlantis Press
SP  - 42
EP  - 45
SN  - 2352-5401
UR  - https://doi.org/10.2991/bme-15.2015.8
DO  - 10.2991/bme-15.2015.8
ID  - Ma2015/09
ER  -