The Effect of Doses of Red Shoot Leaf Extract (Syzygium myrtifolium Walp) on Decreased Cholesterol Total Levels in Male White Wistar Rats In Vivo

DOI

10.2991/978-94-6463-284-2_31How to use a DOI?

Keywords

Red Shoot Leaf Extract; Cholesterol Total Levels; Male White Wistar Rats

Abstract

The prevalence of cholesterol in Indonesia is 66.41%. Central Java is among the five provinces with the highest levels of consumption of fatty, cholesterol, and fried foods, at 60.3%. The purpose of this study was to determine the effect of an extract of red shoot leaves (Syzyginium myrtifolium Walp) on decreasing the profile value of total cholesterol levels in male Wistar strain white rats. Red sprout leaf extract was obtained using the maceration process. Red shoot leaf extract contains anthocyanin compounds that can lower cholesterol, flavonoid compounds, and tannin compounds. his research is a purely experimental design with a before-and-after test with a control group using 30 rats divided into 5 groups, negative control (rats with hypercholesterolemia and Na-CMC 0.5%), positive controls (rats with hypercholesterolemia and 10 mg simvastatin), administration of red shoot leaf extract at extract dose 1 (200 Mg/Kg BW), extract dose 2 (250 Mg/Kg BW), and extract dose 3 (300 Mg/Kg BW). The total number of test animals used was 30 animals, each group consisted of 5 rats. The results of the ANOVA repeated measures test/Friedman test analysis showed that the activity of The Red shoot leaves (Syzyginium myrtifolium Walp) as a cholesterol-lowering agent for reducing total cholesterol levels was demonstrated with the potential efficacy in extract group 3 (300 mg/kg BW) with a significant value of 0.647.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Denih Agus Setia Permana
AU  - Mika Tri Kumala Swandari
AU  - Imam Agus Faizal
AU  - Dini Puspodewi
AU  - Aprilia Iin Aminia Putri
PY  - 2023
DA  - 2023/11/09
TI  - The Effect of Doses of Red Shoot Leaf Extract (Syzygium myrtifolium Walp) on Decreased Cholesterol Total Levels in Male White Wistar Rats In Vivo
BT  - Proceedings of the 4th Borobudur International Symposium on Science and Technology 2022 (BIS-STE 2022)
PB  - Atlantis Press
SP  - 262
EP  - 273
SN  - 2352-5401
UR  - https://doi.org/10.2991/978-94-6463-284-2_31
DO  - 10.2991/978-94-6463-284-2_31
ID  - Permana2023
ER  -