Three Monoterpenoids Eucommiol from The Leaves of Eucommia Ulmoides Protect against Neurotoxicity in PC12 Cells

DOI

10.2991/bep-16.2017.30How to use a DOI?

Keywords

leaves of Eucommia ulmoides; Cyclohexenone; Eucommiol; PC12

Abstract

One new monoterpenoid compound 4'-acetyl-eucommiol (1) and two known compounds eucommiol(2), 1-deoxyeucommiol(3) were isolated from the leaves of Eucommia ulmoides. The structures of the new monoterpenoid eucommiol were elucidated by means of chemical evidence and 1D-and 2D-NMR (1H, 13C, HSQC, HMBC, 1H-1H COSY and NOESY) spectroscopic analysis and HR-ESI-MS. We also investigated the protective effect of compounds 1-3 on the neurotoxicity of PC12 cells induced by amyloid-beta (Aβ 25-35), respectively. As a result, compounds 1 and 2 were seen to afford protection against Aβ-induced toxicity in PC12 cells.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Yueming ZUO
AU  - Zhongli ZHANG
PY  - 2016/12
DA  - 2016/12
TI  - Three Monoterpenoids Eucommiol from The Leaves of Eucommia Ulmoides Protect against Neurotoxicity in PC12 Cells
BT  - Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)
PB  - Atlantis Press
SP  - 143
EP  - 145
SN  - 2468-5747
UR  - https://doi.org/10.2991/bep-16.2017.30
DO  - 10.2991/bep-16.2017.30
ID  - ZUO2016/12
ER  -