Synthesis and Performance of A Novel Penetration Enhancer

DOI

10.2991/bep-16.2017.7How to use a DOI?

Keywords

component; diclofenac potassium; hydrosilication; enhancement ratios; transdermal velocity; 1-menthol

Abstract

Preparation and percutaneous absorption of 2-methyl-2-perfluoro-2'-methyl-3'-oxoca- proyloxyl ethoxycarbonyl ethylmethyldipolyethoxylsilicane (V) were investigated. V was synthesized from 2-perfluoro-2'-methyl-3'-oxocaproyloxylethyl methacrylate and methyldichlorosilicane by hydrosilication, then by alcoholysis with polyglycol, and was characterized by FTIR and MS. The penetration percentage of diclofenac sodium in different solutions of 2% 1-menthol, 0.5% V, 2% 1-menthol-0.5% V and 2% azone were respectively determined with improved Franz equipment and using rat skin as transderma barrier. The enhancement ratios were 3.11, 1.19, 5.46 and 6.21, respectively. V with 1-menthol could improve the trasdermal amount of diclofenac sodium, especially, but sole V express bad performance for it.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Qin WU
AU  - Lei TANG
AU  - Haimin SHEN
AU  - Hongxin SHI
PY  - 2016/12
DA  - 2016/12
TI  - Synthesis and Performance of A Novel Penetration Enhancer
BT  - Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)
PB  - Atlantis Press
SP  - 30
EP  - 33
SN  - 2468-5747
UR  - https://doi.org/10.2991/bep-16.2017.7
DO  - 10.2991/bep-16.2017.7
ID  - WU2016/12
ER  -