Effects of Total Flavonoids of Rosa Chinensis on Focal Cerebral Ischemia Reperfusion Model in Mice

DOI

10.2991/bep-16.2017.5How to use a DOI?

Keywords

total flavonoids of rosa chinensis; focal cerebral ischemia reperfusion; animal model

Abstract

To observe the effects of total flavonoids of Rosa chinensis on focal cerebral ischemia reperfusion model in mice, Method: Nimodipine group, cerebral collaterals group, large, medium and small doses group of the Rosa chinensis total flavonoids were administered with corresponding drugs; Sham operation group, model group were administered the same volume of 0.5%CMC, 1 times a day, continuous administration of 7d. After 1h at 7d to medicine, the focal cerebral ischemia reperfusion model was made by thread embolism method, The blank group only exposed the left blood vessel without Plugging wire, the model mice were only embolism in the left middle cerebral artery to establish an animal model of middle cerebral artery occlusion and reperfusion (MCAO).Result: Compared with the model group, total flavonoids of Rosa chinensis can significantly reduce the loss of neurological function score, animal mortality, serum S-100 beta protein content, reduce the infarct size, the brain tissue has a protective effect. Conclusion: the total flavonoids of Rosa chinensis in each dose group have a better effect on focal cerebral ischemia reperfusion model in mice.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Xiaoli YAN
AU  - Huisu WU
AU  - Xiaoyan FANG
AU  - Minsan MIAO
PY  - 2016/12
DA  - 2016/12
TI  - Effects of Total Flavonoids of Rosa Chinensis on Focal Cerebral Ischemia Reperfusion Model in Mice
BT  - Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)
PB  - Atlantis Press
SP  - 22
EP  - 26
SN  - 2468-5747
UR  - https://doi.org/10.2991/bep-16.2017.5
DO  - 10.2991/bep-16.2017.5
ID  - YAN2016/12
ER  -