A Novel Biphasic Scaffold with Gradient Pore Structures for Osteochondral Tissue Engineering

DOI

10.2991/bep-16.2017.2How to use a DOI?

Keywords

gradient scaffold; 3D printing

Abstract

This study was aimed at using biomimetic strategies to construct a biphasic scaffold. Biphasic scaffolds were constructed using the 3-dimentional printing technology with two phases: the bony phase and the chondral phase. The bony phase was using the composition of poly (lactide-co-glycolide) (PLGA) and Polyethylene glycol PEG; the chondral phase was using hydrogel consisting of GelMA and hyaluronic acid. Also we designed a gradient pore size in the bony phase to better mimic the natural bone tissue. In vitro tests have shown the stratified scaffolds with gradient designs were effective for the multi-tissue formation.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Duo PAN
AU  - Ruixue YIN
AU  - Hongbo ZHANG
AU  - Shengbing YANG
AU  - Wenjun ZHANG
PY  - 2016/12
DA  - 2016/12
TI  - A Novel Biphasic Scaffold with Gradient Pore Structures for Osteochondral Tissue Engineering
BT  - Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)
PB  - Atlantis Press
SP  - 6
EP  - 10
SN  - 2468-5747
UR  - https://doi.org/10.2991/bep-16.2017.2
DO  - 10.2991/bep-16.2017.2
ID  - PAN2016/12
ER  -