Exocyst Regulates Drosophila Border Cell Migration and Wing Development

DOI

10.2991/bbbs-18.2018.36How to use a DOI?

Keywords

Drosophila exocyst; Drosophila melanogaster; Sec3-GFP.

Abstract

Cell migration plays an important role in many physiological and pathological processes. Understanding of the mechanisms of cell migration may lead us to develop novel therapeutic strategies for controlling human disease. Border cell migration in the ovary of Drosophila melanogaster has emerged as an excellent model for studying cell migration in vivo. In a previous study, we have found that the gene sec3 that encodes a component of Drosophila exocyst is required for border cell migration. In the following study, we found that high levels of Sec3-GFP are seen in the leading edge of migratory border cells, and sec3 functions together with other genes encoding exocyst components. Moreover, knockdown of exocyst components induces aberrant wing development. The results implicates that exocyst components play important roles in Dosophila border cell migration and wing development, and function as a complex as they have been found in yeast.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Ping Wan
AU  - Sumei Zheng
AU  - Ting Liao
PY  - 2018/04
DA  - 2018/04
TI  - Exocyst Regulates Drosophila Border Cell Migration and Wing Development
BT  - Proceedings of the 2018 International Workshop on Bioinformatics, Biochemistry, Biomedical Sciences (BBBS 2018)
PB  - Atlantis Press
SP  - 165
EP  - 168
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbbs-18.2018.36
DO  - 10.2991/bbbs-18.2018.36
ID  - Wan2018/04
ER  -