Observation of synergistic effect of End statin and cisplatin On Calu-6 cell

DOI

10.2991/bbbs-18.2018.4How to use a DOI?

Keywords

End statin, Calu-6, apoptosis

Abstract

End statin is an endogenous inhibitor of angiogenesis, specifically acting on endothelial cells, inhibiting its migration, inducing its apoptosis, thus inhibiting the forming of new vessels and tumor growth. But it is not clear about the synergetic mechanism, action characteristic and best regimen. This paper we choosing Calu-6, the human lung adenocarcinoma cell, to observe end statin with/without cisplatin inhibiting growth and inducing apoptosis and the synergetic effect, to provide the experimental evidence for clinical application. The result indicated that End statin can inhibit growth of Calu-6 cell and induce its apoptosis with the mechanism concerned with the down-regulation of Bcl-2. End statin has synergistic effect with Cisplatin, especially in simultaneous administration of two drugs. End statin maybe has an optimistic dosage of action. The mechanisms of End statins’ effect are similar

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Xin Cheng
AU  - Qiuju Lin
AU  - Wenhui Li
PY  - 2018/04
DA  - 2018/04
TI  - Observation of synergistic effect of End statin and cisplatin On Calu-6 cell
BT  - Proceedings of the 2018 International Workshop on Bioinformatics, Biochemistry, Biomedical Sciences (BBBS 2018)
PB  - Atlantis Press
SP  - 15
EP  - 18
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbbs-18.2018.4
DO  - 10.2991/bbbs-18.2018.4
ID  - Cheng2018/04
ER  -