Effect of Ethanol Extract of Robusta Coffee (Coffea canephora) on the Function of the Liver and Kidney of Wistar Rat

DOI

10.2991/ahsr.k.210723.017How to use a DOI?

Keywords

ALT, AST, coffee, creatinine, urea

Abstract

Phytochemical tests of coffee show that coffee contains antioxidant compounds, which play a role in the healing process of disease. However, it is necessary to know the safe dosage of coffee extract used in treating diseases including its effect on important organs such as the liver and kidneys. The purpose of this study was to determine the effect of ethanol extract of Robusta coffee beans on the plasma of AST, ALT, urea, and creatinine of Wistar rats. This study used white male Wistar rats which were divided into Group K (control), Group P1 was given ethanol extract of Robusta coffee beans (EECB) with a dose of 625 mg/Kg BW, Group P2 with a dose of 1250 mg/Kg BW. Group P3 dose 2500 mg/Kg BW, Group P4 dose 5000 mg/Kg BW. Examination of ALT, AST, urea, and creatinine by spectrophotometry. The results showed an increase in the mean levels of ALT, AST, and urea rat plasma in the P1-P4 group, and there was a significant difference using the ANOVA test with a p-value <0.05. Creatinine levels did not show any difference. PostHoc Tukey test, AST levels significantly increased in the P1-P4 group, ALT increased in the P3 and P4 groups, while urea in the P4 group. The ethanol extract of Robusta coffee beans increased AST levels at a dose of 625-5000 mg/Kg BW, increased plasma ALT levels at a dose of 2500-5000 mg /Kg BW, and increased urea levels at a dose of 5000 mg/Kg BW.

Copyright

© 2021, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Dewi Ratih Handayani
AU  - Aditya Gilang Nur Pratama
AU  - I Wayan Agus Putra
PY  - 2021
DA  - 2021/07/24
TI  - Effect of Ethanol Extract of Robusta Coffee (Coffea canephora) on the Function of the Liver and Kidney of Wistar Rat
BT  - Proceedings of the 12th Annual Scientific Meeting, Medical Faculty, Universitas Jenderal Achmad Yani, International Symposium on "Emergency Preparedness and Disaster Response during COVID 19 Pandemic" (ASMC 2021)
PB  - Atlantis Press
SP  - 67
EP  - 71
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.210723.017
DO  - 10.2991/ahsr.k.210723.017
ID  - Handayani2021
ER  -