Effect of Sweet Orange and Pomegranate Peel Extract Combination on in Vivo Antidiabetic and Wound Healing Activity

DOI

10.2991/ahsr.k.210723.013How to use a DOI?

Keywords

antidiabetes, wound healing, orange, pomegranate

Abstract

Diabetes mellitus is a disease characterized by increased blood glucose levels (hyperglycemia). Diabetic wound healing is slower than healthy individuals. Both sweet orange (Citrus sinensis) and pomegranate (Punica granatum) peel have an antihyperglycemic effect. This study investigated the effect of the combination of both these plants on blood glucose level and wound healing in alloxan-induced diabetes rats experimentally. Rats were divided into four groups. One group as a normal group and three treatment groups that induced by intraperitoneal injection of a single dose alloxan 200 mg/kg. One week after diabetes induction, full-thickness excision wounds were made in hyperglycemias rats and were divided into diabetes groups that given CMC 1%, the group that given a combination of sweet orange 100 mg/kg and pomegranate 50 mg/kg peel ethanol extract and the group that given combination of sweet orange 200 mg/kg and pomegranate 100 mg/kg peel ethanol extract. The treatment was given for 12 days. Blood glucose levels and the rate of wound closure were measured on the twelfth day. The combination of sweet orange and pomegranate peel extract showed a significant (p ≤ 0.05) reduction in blood glucose and time to wound closure compared with the normal and diabetes control. Based on these results, a combination of sweet orange and pomegranate have a potential effect as an antidiabetic agent and treatment of chronic wounds in diabetes.

Copyright

© 2021, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Evi Sovia
AU  - Rini Sundari Harjono
AU  - R. J. Nurjatin
AU  - Wisna Dirgahasari Asmara
AU  - Aktiva Syifaaur Rohmah
PY  - 2021
DA  - 2021/07/24
TI  - Effect of Sweet Orange and Pomegranate Peel Extract Combination on in Vivo Antidiabetic and Wound Healing Activity
BT  - Proceedings of the 12th Annual Scientific Meeting, Medical Faculty, Universitas Jenderal Achmad Yani, International Symposium on "Emergency Preparedness and Disaster Response during COVID 19 Pandemic" (ASMC 2021)
PB  - Atlantis Press
SP  - 49
EP  - 53
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.210723.013
DO  - 10.2991/ahsr.k.210723.013
ID  - Sovia2021
ER  -