Synthesis of 2-(4-((6-bromo-3-nitroquinolin-4-yl)amino) phenyl)-2-methylpropanenitrile

DOI

10.2991/asei-15.2015.423How to use a DOI?

Keywords

PI3K/mTOR inhibitors,6-bromoquinolin-4-ol,Synthesis

Abstract

2-(4-((6-bromo-3-nitroquinolin-4-yl)amino)phenyl)-2-methylpropanenitril(7) is an important intermediate in many PI3K/mTOR inhibitors. The compound 5 was synthesized from 6-bromoquinolin-4-ol (1) and 2-(4-nitrophenyl)acetonitrile(4) through five steps including nitration, chlorination, alkylation, reduction and substitution. These structures were confirmed by 1HNMR and MS spectrum. The synthetic method of 7 was optimized and can be used to synthesize the derivatives of NVP-BEZ235.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Fei Lei
AU  - Yuanbiao Tu
AU  - Min Wang
AU  - WenHui Wang
AU  - Qidong Tang
AU  - Shan Xu
PY  - 2015/05
DA  - 2015/05
TI  - Synthesis of 2-(4-((6-bromo-3-nitroquinolin-4-yl)amino) phenyl)-2-methylpropanenitrile
BT  - Proceedings of the 2015 International conference on Applied Science and Engineering Innovation
PB  - Atlantis Press
SP  - 2154
EP  - 2157
SN  - 2352-5401
UR  - https://doi.org/10.2991/asei-15.2015.423
DO  - 10.2991/asei-15.2015.423
ID  - Lei2015/05
ER  -