Chiral Separation of R,S Clopidogrel with Monolithic Molecularly Imprinted Polymers

DOI

10.2991/ap3er-15.2015.74How to use a DOI?

Keywords

monolithic column; molecularly imprinted polymers; chiral separation

Abstract

A monolithic column of molecularly imprinted polymer was prepared by an in situ polymerization method with a compound clopidogrel as the template. The molecular recognition capabilities of the prepared monolithic MIP were evaluated by separating the enantiomers. The characteristics of the column and the influences of mobile phases were studied. The results showed that the monolithic column has chiral recognition capability for the template and the enantiomers were baseline separated even in aqueous solution.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Zhiwei Li
AU  - Yanling Gao
AU  - Jin Xia
AU  - Qingguo He
PY  - 2015/06
DA  - 2015/06
TI  - Chiral Separation of R,S Clopidogrel with Monolithic Molecularly Imprinted Polymers
BT  - Proceedings of the 2015 Asia-Pacific Energy Equipment Engineering Research Conference
PB  - Atlantis Press
SP  - 314
EP  - 317
SN  - 2352-5401
UR  - https://doi.org/10.2991/ap3er-15.2015.74
DO  - 10.2991/ap3er-15.2015.74
ID  - Li2015/06
ER  -