Survey of Estrogenic Activity of Organic Extracts from Water Body from Jilin City Reach of the Second Songhua River

DOI

10.2991/ap3er-15.2015.57How to use a DOI?

Keywords

water pollution;organic extracts; estrogenic activity; MCF- 7;Bcl-2;Bax

Abstract

Objective: To survey estrogenic activity of Environmental estrogens (EEs) pollution in Songhua River water of the second Songhua River.Methods: human breast cancer MCF-7 cell proliferation experiment were used to detect estrogenic activity of organic extracts of organic extracts from water body. Results : MCF- 7 cell proliferation rate increased at first and later decreased with the organic extracts concentration. Bcl-2 mRNA expression of MCF-7 cell increased and Bax mRNA expression decreased with the concentration of organic matter. Cell proliferation was the fastest in organic extracts group equivalent to the raw water 1000 mLConclusion :The organic extract could promote cell proliferation through the regulation of Bcl-2 and Bax expression. The harm risks on the human body of the organic matter in water still need further research on environmental toxicology and epidemiology.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Hongyan Wang
AU  - Yanli Xi
AU  - Jing Zhang
AU  - Shuguang Jin
PY  - 2015/06
DA  - 2015/06
TI  - Survey of Estrogenic Activity of Organic Extracts from Water Body from Jilin City Reach of the Second Songhua River
BT  - Proceedings of the 2015 Asia-Pacific Energy Equipment Engineering Research Conference
PB  - Atlantis Press
SP  - 245
EP  - 248
SN  - 2352-5401
UR  - https://doi.org/10.2991/ap3er-15.2015.57
DO  - 10.2991/ap3er-15.2015.57
ID  - Wang2015/06
ER  -